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Source: Novosibirsk State University – Novosibirsk State University –

Thanks to the new tomograph, Novosibirsk State University expects to quickly pass the stage of preclinical testing of another option for neutron capture therapy (NCT).

Within “Priority 2030” program Novosibirsk State University is actively involved in testing a unique promising method for treating malignant tumors – boron neutron capture therapy (BNCT). The method is based on the ability to selectively accumulate the stable non-radioactive isotope boron-10 in cancer cells. After irradiation with neutrons, a nuclear reaction occurs in such cells with the release of energy, which leads to their death.

One of the options for using this method – using accelerators and a boron-based drug – is being carried out in a consortium with the Institute of Nuclear Physics SB RAS. Clinical trials of this area of BNCT on patients are planned to be carried out from 2025 on the basis of the National Medical Research Center of Oncology named after. N.N. Blokhina.

However, NSU researchers decided not to limit themselves to this treatment option.

— Today in Russia, in fact, the only manufacturer of accelerators of the required type is the Nuclear Physics Institute, and boron-based preparations are not produced in the country. This imposes some restrictions on the scale of implementation of this NRT option in healthcare practice. Therefore, we are simultaneously testing another option, which involves the use of reactors, which, unlike accelerators, operate virtually continuously, and drugs based on gadolinium,” said Candidate of Medical Sciences, Head of the Laboratory of Nuclear and Innovative Medicine Faculty of Physics of NSU Vladimir Kanygin.

According to the scientist, we have noticeably more reactors that, after some modification, can be used in medical institutions, and there are no such problems with the production of gadolinium-based drugs – they have been widely used as contrast compounds for quite a long time.

As a result, scientists from NSU first successfully tested this approach on laboratory rodents in Akademgorodok, and then, in collaboration with colleagues from Tomsk Polytechnic University (TPU), moved on to tests on large animals. The researchers focused on dogs and cats with spontaneous tumors, which typically develop into similar cancers in the same organs as in humans.

— The main problem was studying the dynamics of the condition of four-legged patients after a course of NRT. Until recently, tomographs that can be used to examine large animals were in great short supply. In our region there is only one veterinary clinic and this is a rather expensive service, therefore, if everything is fine with the animal after treatment, its owners are reluctant to use it. And this greatly slowed down the tests, which must take place in strict accordance with accepted protocols,” explained Vladimir Kanygin.

According to the scientist, the process should speed up noticeably due to the fact that NSU has recently also had such a tomograph. He also recalled that this type of research is key in testing NRT technologies before moving on to the next stage – human trials. Based on the results of previous tests and new capabilities in terms of equipment, NSU expects to take this step in the very near future.

Note; This information is raw content directly from the source of the information. This is exactly what the source states and does not reflect the position of MIL-OSI or its clients.

Please note; This information is raw content directly from the information source. It is accurate to what the source is stating and does not reflect the position of MIL-OSI or its clients.

EDITOR’S NOTE: This article is a translation. Apologies should the grammar and or sentence structure not be perfect.

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